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What is the main difference between HSV 1 and HSV 2?

  1. Symptom severity

  2. Treatment methods

  3. Location of sores

  4. Virus structure

The correct answer is: Location of sores

While both HSV 1 and HSV 2 are strains of the herpes virus and have similar symptoms, the main difference between them is the location of the sores. HSV 1 typically causes oral cold sores, while HSV 2 commonly causes genital herpes. Options A and B may seem like plausible differences, but both strains can have varying levels of symptom severity and can be treated with similar methods. Option D may also seem like a possible answer, but both strains have similar virus structures. Therefore, option C is the main difference between the two strains.